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Nanotheranostics 2019; 3(1):1-40. doi:10.7150/ntno.27877 This issue Cite

Review

Theragnostic potentials of core/shell mesoporous silica nanostructures

Aswathy Ravindran Girija^1✉*, Sivakumar Balasubramanian^2*

1. Future Industries Institute, University of South Australia Mawson Lakes Campus, Mawson Lakes 5095, SA, Australia.
2. School of Engineering, University of South Australia Mawson Lakes Campus, Mawson Lakes 5095, SA, Australia.
*Both authors equally contributed

✉ Corresponding author: Aswathy Ravindran Girija, Research Fellow, Future Industries Institute, University of South Australia. Mawson Lakes Campus, Adelaide, SA, 5095, Australia. Email: aswathy.ravindrangirijaedu.au

Abstract

Theragnostics is considered as an emerging treatment strategy that integrates therapeutics and diagnostics thus allowing delivery of therapeutics and simultaneous monitoring of the progression of treatment. Among the different types of inorganic nanomaterials that are being used for nanomedicine, core shell mesoporous silica nanoparticles have emerged as promising multifunctional nanoplatform for theragnostic application. Research in the design of core/shell mesoporous silica nanoparticles is steadily diversifying owing to the various interesting properties of these nanomaterials that are advantageous for advanced biomedical applications. Core/shell mesoporous silica nanoparticles, have garnered substantial attention in recent years because of their exceptional properties including large surface area, low density, ease of functionalization, high loading capacity of drugs, control of the morphology, particle size, tunable hollow interior space and mesoporous shell and possibility of incorporating multifunctional interior core material. In the past decade researcher's demonstrated tremendous development in design of functionalized core/shell mesoporous silica nanoparticles with different inorganic functional nanomaterial incorporated into mesoporous nanosystem for simultaneous therapeutic and diagnostic (theragnostic) applications in cancer. In this review, we recapitulate the progress in commonly used synthetic strategies and theragnostic applications of core/shell mesoporous silica nanoparticles with special emphasis on therapeutic and diagnostic modalities. Finally, we discuss the challenges and some perspectives on the future research and development of theragnostic core/shell mesoporous silica nanoparticles.

Keywords: Theragnostic, Core/shell, Mesoporous silica nanoparticles, Multifunctional, Cancer, Therapeutic, Diagnostic

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