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Nanotheranostics, the sister journal of Theranostics, is a multidisciplinary and fully open access journal. Nanotheranostics publishes innovative and original basic, translational and clinical research reflecting the fields of nanomedicine, nanoimaging, drug and gene delivery, nanoelectronic biosensors, and other areas. 

Regular features include high quality research articles, reviews or mini-reviews, rapid communication of preliminary data on innovative research, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical studies or ethical issues of nanomedicine are also welcome. Timely reviews that provide updates on current applications and issues in nanomedicine and translational aspects of nanotheranostics and other topics are particularly welcome and will be given high priority.

Nanotheranostics employs a rigorous peer-review system, but also strives for rapid review turnaround times and is based on the same streamlined submission platform as Theranostics.

Recent Papers:


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Research Paper
Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis
Brian Mog, Courteney Asase, Alice Chaplin, Huiyun Gao, Sanjay Rajagopalan, Andrei Maiseyeu
Nanotheranostics 2019; 3(4): 342-355. doi:10.7150/ntno.37391
[Abstract] [Full text] [PDF]


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Research Paper
Microbubble enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma
Julia C. D'Souza, Laith R. Sultan, Stephen J. Hunt, Terence P. Gade, Mrigendra B. Karmacharya, Susan M. Schultz, Angela K. Brice, Andrew K. W. Wood, Chandra M. Sehgal
Nanotheranostics 2019; 3(4): 331-341. doi:10.7150/ntno.39514
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas
Changliang Liu, Zijian Zhao, Houqian Gao, Iman Rostami, Qing You, Xinru Jia, Chen Wang, Ling Zhu, Yanlian Yang
Nanotheranostics 2019; 3(4): 311-330. doi:10.7150/ntno.38954
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Theranostic nanoparticles enhance the response of glioblastomas to radiation
Wei Wu, Jessica L. Klockow, Suchismita Mohanty, Kimberly S. Ku, Maryam Aghighi, Stavros Melemenidis, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Ning Zhao, Jürgen Schlegel, Edward E. Graves, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Sudip Mukherjee, Frederick T. Chin, Heike E. Daldrup-Link
Nanotheranostics 2019; 3(4): 299-310. doi:10.7150/ntno.35342
[Abstract] [Full text] [PDF]


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Research Paper
Bacterial magnetosomes loaded with doxorubicin and transferrin improve targeted therapy of hepatocellular carcinoma
Jiaojiao Wang, Yuanyuan Geng, Yunpeng Zhang, Xi Wang, Junquan Liu, Abdul Basit, Ting Miao, Weiquan Liu, Wei Jiang
Nanotheranostics 2019; 3(3): 284-298. doi:10.7150/ntno.34601
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Polydopamine-coated gold nanostar for combined antitumor and antiangiogenic therapy in multidrug-resistant breast cancer
You-Hong You, Yu-Feng Lin, Bhanu Nirosha, Huan-Tsung Chang, Yu-Fen Huang
Nanotheranostics 2019; 3(3): 266-283. doi:10.7150/ntno.36842
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
68Ga-Sienna+ for PET-MRI Guided Sentinel Lymph Node Biopsy: Synthesis and Preclinical Evaluation in a Metastatic Breast Cancer Model
Heli Savolainen, Alessia Volpe, Alkystis Phinikaridou, Michael Douek, Gilbert Fruhwirth, Rafael T. M. de Rosales
Nanotheranostics 2019; 3(3): 255-265. doi:10.7150/ntno.34727
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Co-precipitation Synthesis of Near-infrared Iron Oxide Nanocrystals on Magnetically Targeted Imaging and Photothermal Cancer Therapy via Photoablative Protein Denature
Wei-Jhe Syu, Chih-Chia Huang, Jong-Kai Hsiao, Yao-Chang Lee, Yu-Tsang Huang, Parthiban Venkatesan, Ping-Shan Lai
Nanotheranostics 2019; 3(3): 236-254. doi:10.7150/ntno.24124
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Overcoming hypoxia-induced chemoresistance to cisplatin through tumor oxygenation monitored by optical imaging
Donghui Song, André O'Reilly Beringhs, Zhenwu Zhuang, Gaurav Joshi, Thanh Huyen Tran, Kevin P. Claffey, Hong Yuan, Xiuling Lu
Nanotheranostics 2019; 3(2): 223-235. doi:10.7150/ntno.35935
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Ultrasound-mediated delivery of siESE complexed with microbubbles attenuates HER2+/- cell line proliferation and tumor growth in rodent models of breast cancer
Kang-Ho Song, Tammy Trudeau, Adwitiya Kar, Mark A. Borden, Arthur Gutierrez-Hartmann
Nanotheranostics 2019; 3(2): 212-222. doi:10.7150/ntno.31827
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Tumor-Activatable Clinical Nanoprobe for Cancer Imaging
Derek Reichel, Manisha Tripathi, Pramod Butte, Rola Saouaf, J. Manuel Perez
Nanotheranostics 2019; 3(2): 196-211. doi:10.7150/ntno.34921
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Various Nucleolar Stress Inducers Result in Highly Distinct Changes in Water, Dry Mass and Elemental Content in Cancerous Cell Compartments: Investigation Using a Nano-Analytical Approach
Jean Michel, Frédérique Nolin, Laurence Wortham, Nathalie Lalun, Pavel Tchelidze, Vincent Banchet, Christine Terryn, Dominique Ploton
Nanotheranostics 2019; 3(2): 179-195. doi:10.7150/ntno.31878
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Magnetic Heating Stimulated Cargo Release with Dose Control using Multifunctional MR and Thermosensitive Liposome
Sayoni Ray, Chi-An Cheng, Wei Chen, Zhao Li, Jeffrey I. Zink, Yung-Ya Lin
Nanotheranostics 2019; 3(2): 166-178. doi:10.7150/ntno.31164
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Near-Infrared Organic Fluorescent Nanoparticles for Long-term Monitoring and Photodynamic Therapy of Cancer
Qi Xia, Zikang Chen, Yuping Zhou, Ruiyuan Liu
Nanotheranostics 2019; 3(2): 156-165. doi:10.7150/ntno.33536
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Enhanced Photothermal Treatment Efficacy and Normal Tissue Protection via Vascular Targeted Gold Nanocages
Samir V. Jenkins, Dmitry A. Nedosekin, Barry J. Shaulis, Tengjiao Wang, Azemat Jamshidi-Parsian, Erik D. Pollock, Jingyi Chen, Ruud P.M. Dings, Robert J. Griffin
Nanotheranostics 2019; 3(2): 145-155. doi:10.7150/ntno.32395
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Research Paper
Perfluorocarbon nanodroplets can reoxygenate hypoxic tumors in vivo without carbogen breathing
Yun Xiang, Nicholas Bernards, Bryan Hoang, Jinzi Zheng, Naomi Matsuura
Nanotheranostics 2019; 3(2): 135-144. doi:10.7150/ntno.29908
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Editor-in-Chief:
Moritz F. Kircher, MD, PhD
Chair, Department of Imaging and Radiology
Dana-Farber Cancer Institute &
Harvard Medical School
Editor-in-chief profile

new Congratulations to Dr. Moritz F. Kircher who has been appointed Chair of the Department of Imaging and Radiology, Dana-Farber Cancer Institute, Harvard Medical School!

new In its latest meeting, the Literature Selection Technical Review Committee (LSTRC) has selected Nanotheranostics for inclusion in MEDLINE, the prestigious index of U.S. National Library of Medicine. Congratulations!

Stem cell transplants are an effective approach to repair large bone defects. However, comprehensive techniques to monitor the fate of transplanted stem cells in vivo are lacking. Such strategies would enable corrective interventions at an early stage and greatly benefit the development of more successful tissue regeneration approaches. In this study, we designed and synthesized a dual-modality imaging probe (Feru-AFC) that can simultaneously localize transplanted stem cells and diagnose immune rejection-induced apoptosis at an early stage in vivo. ...
Endoscopy is the gold standard investigation in the diagnosis of gastrointestinal cancers and the management of early and pre-malignant lesions either by resection or ablation. Recently gold nanoparticles have shown promise in cancer diagnosis and therapeutics (theranostics). The combination of multifunctional gold nanoparticles with near infrared fluorescence endoscopy for accurate mapping of early or pre-malignant lesions can potentially enhance diagnostic efficiency while precisely directing endoscopic near infrared photothermal therapy for established cancers. ...
Squalenoylation of gemcitabine, a front-line therapy for pancreatic cancer, allows for improved cellular-level and system-wide drug delivery. The established methods to conjugate squalene to gemcitabine and to form nanoparticles (NPs) with the squalenoylated gemcitabine (SqGem) conjugate are cumbersome, time-consuming and can be difficult to reliably replicate. Further, the creation of multi-functional SqGem-based NP theranostics would facilitate characterization of in vivo pharmacokinetics and efficacy. More ...
Anticancer nanotherapeutics have shown mixed results in clinical trials, raising the questions of whether imaging should be used to i) identify patients with a higher likelihood of nanoparticle accumulation, ii) assess nanotherapeutic efficacy before traditional measures show response, and iii) guide adjuvant treatments to enhance therapeutic nanoparticle (TNP) delivery. Here we review the use of a clinically approved MRI nanoparticle (ferumoxytol, FMX) to predict TNP delivery and efficacy. It is becoming increasingly apparent that nanoparticles used for imaging, despite clearly distinct physicochemical properties, often co-localize with TNP in tumors. This evidence offers the possibility of using FMX as a generic “companion diagnostic” nanoparticle for multiple TNP formulations, thus potentially allowing many of the complex regulatory and cost challenges of other approaches to be avoided. More ...
Congratulations to Dr. Chen for being elected as AIMBE fellow: http://aimbe.org/college-of-fellows/cof-2103/
Congratulations to Dr. Chen for being recognized as Selected Highly Prolific Authors  (most published articles in the past 5 years) for 3 ACS journals (ACS Nano, Bioconjugate Chemistry, and Molecular Pharmaceutics). More details: http://journalstars.acs.org/