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Nanotheranostics 2024; 8(4):458-472. doi:10.7150/ntno.95251 This issue Cite

Review

Peptide Conjugated Boron Neutron Capture Therapy for Enhanced Tumor Targeting

Vaskuri G.S. Sainaga Jyothi¹, Nagavendra Kommineni^2✉

1. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center (UTHSC), Memphis, TN 38163, USA.
2. Center for Biomedical Research, Population Council, New York, NY 10065, USA.

✉ Corresponding author: Dr. Nagavendra Kommineni, nkommineniorg.

Abstract

A cutting-edge non-invasive cancer treatment method called boron neutron capture therapy (BNCT) allows for the removal of cancerous tumor cells with the least possible damage to healthy tissue. It involves the exposure of cancer cells with low-energy thermal neutrons, boron-10 (¹⁰B) cellular uptake causes cancer cell death by producing alpha particles and recoiling lithium-7 (⁷ Li) nuclei. Despite positive outcomes from clinical trials conducted all around the world, these substances have relatively limited tumor selectivity or low boron content per molecule. The development of new boron delivery agents with more selectivity and enhanced boron loading would advance this technique and promote its use in clinics as a primary cancer treatment. As peptide-binding cell surface receptors are typically overexpressed on cancer cells, they can be seen as interesting targets for targeted tumor therapy. The attachment of meta-carboranes to peptide conjugates that target tumor cells specifically by their overexpressed receptors may be a method to get around these problems. A state-of-the-art overview of current developments in the application of BNCT for cancer targeted therapy via peptide conjugation is the goal of this review.

Keywords: BNCT, Peptide conjugation, Tumor targeting, targeting peptides and BNCT designing

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