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Nanotheranostics 2018; 2(1):87-95. doi:10.7150/ntno.21942 This issue Cite

Research Paper

Construction of Multifunctional Fe₃O₄-MTX@HBc Nanoparticles for MR Imaging and Photothermal Therapy/Chemotherapy

Qiang Zhang^2*, Wenjun Shan^1*, Chaochao Ai¹, Zhiwei Chen³, Tiantian Zhou³, Xiaolin Lv¹, Xi Zhou¹, Shefang Ye¹, Lei Ren^{1,4,5 ✉}, Xiumin Wang^{2 ✉}

1. Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, Fujian, P. R. China.
2. School of Pharmaceutical Sciences, Xiamen University, Xiamen 361002, Fujian, P. R. China.
3. Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen 361005, Fujian, P. R. China.
4. Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Xiamen University, Xiamen 361005, Fujian, P. R. China.
5. State Key Lab of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, P. R. China.
*These authors contributed equally to this work.

✉ Corresponding authors: Lei Ren, Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, P. R. China. Email: renleiedu.cn; Xiumin Wang, School of Pharmaceutical Science, Xiamen University, Xiamen 361002, P. R. China. Email: wangxmedu.cn. More

Abstract

To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic Fe₃O₄-MTX@HBc core-shell nanoparticles (NPs) were designed. A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into the engineered virus-like particles (VLPs) through the affinity of histidine tags for the methotrexate (MTX)-Ni²⁺ chelate. HBc₁₄₄-His VLPs shell could protect Fe₃O₄-MTX NPs from the recognition by the reticuloendothelial system as well as could increase their cellular uptake efficiency. Through our well-designed tactic, the photothermal efficiency of Fe₃O₄ NPs were obviously improved in vitro and in vivo upon near-infrared (NIR) laser irradiation. Moreover, Magnetic resonance imaging (MRI) results showed that the Fe₃O₄-MTX@HBc core-shell NPs were reliable T₂-type MRI contrast agents for tumor imaging. Hence the Fe₃O₄-MTX@HBc core-shell NPs may act as a promising theranostic platform for multimodal cancer treatment.

Keywords: Virus-Like Nanoparticles, MRI, Chemotherapy, Photothermal Therapy, Theranostic

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