Nanotheranostics 2018; 2(1):42-58. doi:10.7150/ntno.19974


Upregulation of osteogenesis of mesenchymal stem cells with virus-based thin films

Huong Giang Nguyen1,2, Kamolrat Metavarayuth1, Qian Wang1✉

1. Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA
2. National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA

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Nguyen HG, Metavarayuth K, Wang Q. Upregulation of osteogenesis of mesenchymal stem cells with virus-based thin films. Nanotheranostics 2018; 2(1):42-58. doi:10.7150/ntno.19974. Available from

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A major aim of tissue engineering is to develop biomimetic scaffolding materials that can guide the proliferation, self-renewal and differentiation of multipotent stem cells into specific lineages. Cellular functions can be controlled by the interactions between cells and biomaterials. Therefore, the surface chemistry and topography of support materials play a pivotal role in modulating cell behaviors at many stages of cell growth and development. Due to their highly ordered structure and programmable surface chemistries, which provide unique topography as biomaterials, viral nanoparticles have been utilized as building blocks for targeted cell growth and differentiation. This review article discusses the fabrication of two-dimensional virus-based thin film on substrates and highlights the study of the effect of chemical and physical cues introduced by plant virus nanoparticle thin films on the promotion of osteogenic differentiation of BMSCs.

Keywords: Plant virus, viral nanoparticles, thin-film, osteogenic differentiation, mesenchymal stem cells