Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy

Junseok Lee¹, Yeong Mi Lee², Jinhwan Kim^{1, 2}, Won Jong Kim^{1, 2✉}

1. Center for Self-assembly and Complexity, Institute of Basic Science (IBS), Pohang, 37673, Korea;
2. Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Korea.

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Citation:
Lee J, Lee YM, Kim J, Kim WJ. Doxorubicin/Ce6-Loaded Nanoparticle Coated with Polymer via Singlet Oxygen-Sensitive Linker for Photodynamically Assisted Chemotherapy. Nanotheranostics 2017; 1(2):196-207. doi:10.7150/ntno.18576. Available from https://www.ntno.org/v01p0196.htm

Abstract

It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed in vitro and in vivo. This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy.

Keywords: Mesoporous silica, Singlet oxygen, Photodynamic therapy, Chemotherapy, Photochemical internalization.