Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging

Behrends, André; Wei, Huimin; Neumann, Alexander; Friedrich, Thomas; Bakenecker, Anna C.; Franke, Jochen; Sajjamark, Kulthisa; Buchholz, Oliver; Bär, Sébastien; Hofmann, Ulrich G.; Graeser, Matthias; Buzug, Thorsten M.

doi:10.7150/ntno.90360

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Theranostics

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Nanotheranostics 2024; 8(2):163-178. doi:10.7150/ntno.90360 This issue Cite

Research Paper

Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging

André Behrends^1#✉, Huimin Wei^1#✉, Alexander Neumann², Thomas Friedrich¹, Anna C. Bakenecker¹, Jochen Franke³, Kulthisa Sajjamark³, Oliver Buchholz⁴, Sébastien Bär⁴, Ulrich G. Hofmann⁴, Matthias Graeser^1,2, Thorsten M. Buzug^1,2

1. Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering (IMTE), Lübeck, Germany.
2. Institute of Medical Engineering (IMT), University of Lübeck, Lübeck, Germany.
3. Bruker BioSpin MRI GmbH, Preclinical Imaging Division, Ettlingen, Germany.
4. Section for Neuroelectronic Systems, Department of Neurosurgery, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
# These authors contributed equally.

Citation:

Behrends A, Wei H, Neumann A, Friedrich T, Bakenecker AC, Franke J, Sajjamark K, Buchholz O, Bär S, Hofmann UG, Graeser M, Buzug TM. Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging. Nanotheranostics 2024; 8(2):163-178. doi:10.7150/ntno.90360. https://www.ntno.org/v08p0163.htm

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Abstract

Background: Combining magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH) offers the ability to perform localized hyperthermia and magnetic particle imaging-assisted thermometry of hyperthermia treatment. This allows precise regional selective heating inside the body without invasive interventions. In current MPI-MFH platforms, separate systems are used, which require object transfer from one system to another. Here, we present the design, development and evaluation process for integrable MFH platforms, which extends a commercial MPI scanner with the functionality of MFH.

Methods: The biggest issue of integrating magnetic fluid hyperthermia platforms into a magnetic particle imaging system is the magnetic coupling of the devices, which induces high voltage in the imaging system, and is harming its components. In this paper, we use a self-compensation approach derived from heuristic algorithms to protect the magnetic particle imaging scanner. The integrable platforms are evaluated regarding electrical and magnetic characteristics, cooling capability, field strength, the magnetic coupling to a replica of the magnetic particle imaging system's main solenoid and particle heating.

Results: The MFH platforms generate suitable magnetic fields for the magnetic heating of particles and are compatible with a commercial magnetic particle imaging scanner. In combination with the imaging system, selective heating with a gradient field and steerable heating positioning using the MPI focus fields are possible.

Conclusion: The proposed MFH platforms serve as a therapeutic tool to unlock the MFH functionality of a commercial magnetic particle imaging scanner, enabling its use in future preclinical trials of MPI-guided, spatially selective magnetic hyperthermia therapy.

Keywords: magnetic particle imaging, magnetic fluid hyperthermia, imaging-guided treatment, theranostics

Citation styles

APA

Behrends, A., Wei, H., Neumann, A., Friedrich, T., Bakenecker, A.C., Franke, J., Sajjamark, K., Buchholz, O., Bär, S., Hofmann, U.G., Graeser, M., Buzug, T.M. (2024). Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging. Nanotheranostics, 8(2), 163-178. https://doi.org/10.7150/ntno.90360.

ACS

Behrends, A.; Wei, H.; Neumann, A.; Friedrich, T.; Bakenecker, A.C.; Franke, J.; Sajjamark, K.; Buchholz, O.; Bär, S.; Hofmann, U.G.; Graeser, M.; Buzug, T.M. Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging. Nanotheranostics 2024, 8 (2), 163-178. DOI: 10.7150/ntno.90360.

NLM

CSE

Behrends A, Wei H, Neumann A, Friedrich T, Bakenecker AC, Franke J, Sajjamark K, Buchholz O, Bär S, Hofmann UG, Graeser M, Buzug TM. 2024. Integrable Magnetic Fluid Hyperthermia Systems for 3D Magnetic Particle Imaging. Nanotheranostics. 8(2):163-178.

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