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Nanotheranostics 2020; 4(3):107-118. doi:10.7150/ntno.29522 This issue Cite

Research Paper

Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer

Eleanor McCabe-Lankford1, Bryce McCarthy1, Margarita Arakelyan- Peters Berwick1, Kiarash Salafian1, Laura Galarza-Paez1, Santu Sarkar1, John Sloop2, George Donati2, April J. Brown1, Nicole Levi-Polyachenko1✉

1. Department of Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
2. Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.

✉ Corresponding author: Levi-Polyachenko. E-mail: nleviedu.

Citation:
McCabe-Lankford E, McCarthy B, Berwick MAP, Salafian K, Galarza-Paez L, Sarkar S, Sloop J, Donati G, Brown AJ, Levi-Polyachenko N. Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer. Nanotheranostics 2020; 4(3):107-118. doi:10.7150/ntno.29522. https://www.ntno.org/v04p0107.htm
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Abstract

Graphic abstract

Nanoparticles offer many promising advantages for improving current surgical regimens through their ability to detect and treat disseminated colorectal cancer (CRC). Hybrid Donor-Acceptor Polymer Particles (HDAPPs) have recently been shown to fluorescently detect and thermally ablate tumors in a murine model. Here, HDAPPS were functionalized with hyaluronic acid (HA) to improve their binding specificity to CT26 mouse CRC cells using HA to target the cancer stem cell marker CD44. In this work, we compared the binding of HA functionalized HDAPPs (HA-HDAPPs) in in vitro, ex vivo, and in vivo environments. The HA-HDAPPs bound to CT26 cells 2-fold more in vitro and 2.3-fold higher than un-functionalized HDAPPs ex vivo. Compared to intraoperative abdominal perfusion, intraperitoneal injection prior to laser stimulation for nanoparticle heat generation provides a superior modality of HA-HDAPPs delivery for CRC tumor selectivity. Photothermal treatment of disseminated CRC showed that only HA-HDAPPs delivered via intraperitoneal injection had a reduction in the tumor burden, and these nanoparticles also remained in the abdomen following resolution of the tumor. The results of this work confirm that HA-HDAPPs selectively bind to disseminated CRC, with ex vivo tumors having bound HA-HDAPPs capable of photothermal ablation. HA-HDAPPs demonstrated superior binding to tumor regions compared to HDAPPs. Overall, this study displays the theranostic potential of HDAPPs, emphasizing their capacity to detect and photothermally treat disseminated CRC tumors.

Keywords: Hybrid Donor-Acceptor Polymer Particles, HDAPPS, disseminated colorectal cancer, nanoparticles

Citation styles

APA
McCabe-Lankford, E., McCarthy, B., Berwick, M.A.P., Salafian, K., Galarza-Paez, L., Sarkar, S., Sloop, J., Donati, G., Brown, A.J., Levi-Polyachenko, N. (2020). Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer. Nanotheranostics, 4(3), 107-118. https://doi.org/10.7150/ntno.29522.

ACS
McCabe-Lankford, E.; McCarthy, B.; Berwick, M.A.P.; Salafian, K.; Galarza-Paez, L.; Sarkar, S.; Sloop, J.; Donati, G.; Brown, A.J.; Levi-Polyachenko, N. Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer. Nanotheranostics 2020, 4 (3), 107-118. DOI: 10.7150/ntno.29522.

NLM
McCabe-Lankford E, McCarthy B, Berwick MAP, Salafian K, Galarza-Paez L, Sarkar S, Sloop J, Donati G, Brown AJ, Levi-Polyachenko N. Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer. Nanotheranostics 2020; 4(3):107-118. doi:10.7150/ntno.29522. https://www.ntno.org/v04p0107.htm

CSE
McCabe-Lankford E, McCarthy B, Berwick MAP, Salafian K, Galarza-Paez L, Sarkar S, Sloop J, Donati G, Brown AJ, Levi-Polyachenko N. 2020. Binding of Targeted Semiconducting Photothermal Polymer Nanoparticles for Intraperitoneal Detection and Treatment of Colorectal Cancer. Nanotheranostics. 4(3):107-118.

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